ChemicalBook CAS DataBase List Cilofexor

Cilofexor synthesis

3synthesis methods

Product Name:Cilofexor
CAS Number:1418274-28-8
Molecular formula:C28H22Cl3N3O5
Molecular Weight:586.85

4-((4-Bromo-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-isoxazole

1418274-31-3
1 suppliers
inquiry

1418274-28-8
70 suppliers
$34.00/1mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: isopropylmagnesium bromide / tetrahydrofuran / 1 h / 40 °C / Inert atmosphere
1.2: 16 h / -30 - 20 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 20 - 30 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C
4.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 16 h / 20 - 30 °C

References:

CN115215853,2022,A

4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

1268245-50-6
54 suppliers
$60.00/50mg

1418274-28-8
70 suppliers
$34.00/1mg

References

855403-42-8 Synthesis

855403-42-8
67 suppliers
$12.00/100mg

1418274-28-8
70 suppliers
$34.00/1mg

References