ChemicalBook CAS DataBase List Cyclohexylideneacetic acid methyl ester

Cyclohexylideneacetic acid methyl ester synthesis

12synthesis methods

Product Name:Cyclohexylideneacetic acid methyl ester
CAS Number:40203-74-5
Molecular formula:C9H14O2
Molecular Weight:154.21

108-94-1 Synthesis

108-94-1
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21204-67-1 Synthesis

methyl (triphenylphosphoranylidene)acetate

21204-67-1
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40203-74-5
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Yield:40203-74-5 21%

Reaction Conditions:

in toluene;Heating / reflux;

Steps:

5

Example 5Synthesis of Compound 802 To a stirred solution of cyclohexanone 801 (15.O g, 153 mmol) in toluene (100 rnL) was added methoxycarbonylmethylene triphenylphosphorane (52.8 g, 153 mmol). The reaction mixture was re fluxed overnight. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with water and brine and dried over anhydrous sodium sulfate to afford product cyclohexylidene-acetic acid methyl ester 802 (5.0 g, 21%). ¹H NMR (200 MHz, CDCl₃): δ 1.6-2.0 (m, 10H), 3.7 (s, 3H), 5.6(s, IH).

References:

WO2008/73623,2008,A2 Location in patent:Page/Page column 93

5927-18-4 Synthesis