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Cyclopentanone, 2-(2-propyn-1-yl)- synthesis

9synthesis methods
-

Yield:19842-40-1 15%

Reaction Conditions:

Stage #1: cyclopentanonewith pyrrolidine;toluene-4-sulfonic acid in benzene; for 1.5 h;Heating;
Stage #2: propargyl bromidewith triethylamine in toluene;acetonitrile;benzene at 20; for 15 h;

References:

Harrison, Tyler J.;Kozak, Jennifer A.;Corbella-Pane, Montserrat;Dake, Gregory R. [Journal of Organic Chemistry,2006,vol. 71,# 12,p. 4525 - 4529]