Cyclopentyl chloroformate synthesis
- Product Name:Cyclopentyl chloroformate
- CAS Number:50715-28-1
- Molecular formula:C6H9ClO2
- Molecular Weight:148.59
32315-10-9
411 suppliers
$10.00/1g
96-41-3
238 suppliers
$10.00/10g
50715-28-1
165 suppliers
$14.00/1g
Yield:50715-28-1 97.4%
Reaction Conditions:
with triethylamine in dichloromethane at -5 - 20; for 13 h;
Steps:
11 Example 1
General procedure: In a jacketed reactor equipped with a mechanical stirrer, a thermometer, a constant pressure dropping funnel and an exhaust gas absorber,Add 7L dichloromethane, the first reaction phase, temperature -5 ° C,780 g (5 mol) of L-menthol and 1187 g (4 mol) of triphosgene were added in portions and sufficiently stirred to dissolve them.-5 ° CDrop under the drop1215 g (12mo 1) triethylamine in methylene chloride (1.8 L) was added dropwise over 1 to 2 h,Insulation reaction 3h after the natural temperature rise to the second reaction stage, temperature control 25 ° C, stirring about 10h.After completion of the reaction, the reaction mixture was separated by filtration under filtration, and the mother liquor was washed successively with 3 L of water, 3 L of dilute hydrochloric acid (5%), 0.5 L of sodium carbonate (5%) and 0.5 L of saturated brine ,After drying over anhydrous sodium sulfate, the solvent was removed by steaming and distilled under reduced pressure to collect 108 to 109 ° C / 1 ImmHg fraction,1063 g of a colorless liquid was obtained in a yield of 97.2%.
References:
Yangtze University;WU, Ai-bin;QIN, Shao-xiong;LI, Peng-Fei;GUO, Quanjing;HU, Bao-jun CN106045802, 2016, A Location in patent:Paragraph 0044-0045
32315-10-9
411 suppliers
$10.00/1g
1003-03-8
211 suppliers
$10.00/1g
50715-28-1
165 suppliers
$14.00/1g
96-41-3
238 suppliers
$10.00/10g
503-38-8
109 suppliers
$15.00/5g
50715-28-1
165 suppliers
$14.00/1g