ChemicalBook CAS DataBase List DBCO-PEG4-SE

DBCO-PEG4-SE synthesis

9synthesis methods

Product Name:DBCO-PEG4-SE
CAS Number:1427004-19-0
Molecular formula:C34H39N3O10
Molecular Weight:649.69

2222-33-5 Synthesis

2222-33-5
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$6.00/5g

1427004-19-0
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$37.00/1MG

Yield:-

Steps:

Multi-step reaction with 8 steps
1: hydroxyamino hydrochloride; pyridine / ethanol / 15 h / Reflux
2: diisobutylaluminium hydride / dichloromethane; toluene / -5 - 20 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
4: bromine / dichloromethane / 2 h / 0 °C / Inert atmosphere
5: potassium-t-butoxide / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
6: N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride / dichloromethane / 20 °C
7: triethylamine / N,N-dimethyl-formamide / 20 °C
8: N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride / dichloromethane / 20 °C

References:

WO2018/89373,2018,A2