decahydroquinoline-2-carboxylic Acid Hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride;PtO₂ in acetic acid;

Steps:

13.A Step A

Step A Synthesis of Decahydro-quinoline-2-carboxylic Acid Hydrochloride A mixture of PtO₂ (25 wt. %) and 2-quinolinecarboxylic acid (Aldrich) in acetic acid was hydrogenated at RT under 60 Psi overnight. The reaction mixture was stripped to dryness. Concentrated HCl was added and stripped to dryness to give the title compound as a white solid. C₁₀H₁₇NO₂ (free base, MW=183.26); mass spectroscopy (MH⁺) 184.

References:

US6528505,2003,B1