ChemicalBook CAS DataBase List Dexmedetomidine

Dexmedetomidine synthesis

7synthesis methods

Product Name:Dexmedetomidine
CAS Number:113775-47-6
Molecular formula:C13H16N2
Molecular Weight:200.28

86347-14-0 Synthesis

86347-14-0
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$5.00/10mg

113775-47-6
158 suppliers
$10.00/1mg

Yield:113775-47-6 94.2%

Reaction Conditions:

Stage #1:medetomidine with L-Lysine ethyl ester in ethanol at 75; for 3 h;
Stage #2: with sodium hydroxide in water at 100;enantioselective reaction;Temperature;

Steps:

5 Example 5-(S) -4- [1- (2,3-dimethylphenyl) ethyl] -1H-imidazole
30 g of sulfonated 4- [1- (2,3-dimethylphenyl) ethyl] -1H-imidazole with 22.4 g (120 mmol) of lysine ethyl ester In anhydrous ethanol 75 ° C stirring salt for 3 hours, The reaction was terminated and the filtrate was allowed to stand to obtain (S) - salt. The above (S) - salt was added to 20 ml of a 2 mol / L aqueous solution of sodium hydroxide and stirred at 100 ° C, Monitoring to the end of the reaction, the reaction solution cooled to room temperature, The reaction solution was then extracted with methylene chloride, Concentrated under reduced pressure, recrystallized petroleum ether, Dried in vacuo to give (S) -4- [1- (2,3-dimethylphenyl) ethyl] -111-imidazole 20.28, Yield 94.2%, 66 value 99.57%.

References:

Tsingtao Chenda Biological Technology Co., Ltd.;Lv Yanhua CN106632053, 2017, A Location in patent:Paragraph 0034-0036

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176721-03-2 Synthesis