![](/CAS/GIF/145-13-1.gif)
Pregnenolone synthesis
- Product Name:Pregnenolone
- CAS Number:145-13-1
- Molecular formula:C21H32O2
- Molecular Weight:316.48
![3-tert-Butyldimethylsilyloxy Pregnenolone](/CAS2/GIF/58701-45-4.gif)
58701-45-4
5 suppliers
$120.00/5mg
![Pregnenolone](/CAS/GIF/145-13-1.gif)
145-13-1
487 suppliers
$28.00/500mg
Yield:145-13-1 97%
Reaction Conditions:
with chloro-methylsulfanyl-methane;water;potassium iodide in 1,4-dioxane at 50; for 3.3 h;
Steps:
Deprotection of silyl ethers; the desilylation of 1a
General procedure: Protected diosgenin 1a (200 mg, 1 equiv.), chloromethyl methyl sulfide (4 mg, 0.1 equiv.), KI (2 mg, 0.03 equiv.), dioxane (4.0 mL)and water (102 mg, 15 equiv.) were added to a 25 mL round-bottom flask. The mixture was then stirred at 50 °C for 2.3 h. The solvent was then removed under reduced pressure for silica gel chromatography to furnish diosgenin 1aa as: White solid; yield 152 mg (>99%).
References:
Niu, Qun;Xing, Linlin;Li, Chunbao [Journal of Chemical Research,2017,vol. 41,# 6,p. 358 - 364]
![16-Dehydropregnenolone acetate](/CAS/GIF/979-02-2.gif)
979-02-2
284 suppliers
$20.00/100mg
![Pregnenolone](/CAS/GIF/145-13-1.gif)
145-13-1
487 suppliers
$28.00/500mg
![Pregnenolone acetate](/CAS/GIF/1778-02-5.gif)
1778-02-5
244 suppliers
$12.00/1mg
![Pregnenolone](/CAS/GIF/145-13-1.gif)
145-13-1
487 suppliers
$28.00/500mg
![20ALPHA-HYDROXYCHOLESTEROL](/CAS/GIF/516-72-3.gif)
516-72-3
70 suppliers
$44.00/1mg
![Pregnenolone](/CAS/GIF/145-13-1.gif)
145-13-1
487 suppliers
$28.00/500mg
![beta-Sitosterol](/CAS/GIF/83-46-5.gif)
83-46-5
552 suppliers
$5.00/250mg
![Pregnenolone](/CAS/GIF/145-13-1.gif)
145-13-1
487 suppliers
$28.00/500mg