![](/CAS/20210111/GIF/146607-19-4.gif)
Diclofenac Related Compound 7 synthesis
- Product Name:Diclofenac Related Compound 7
- CAS Number:146607-19-4
- Molecular formula:C14H11Cl2NO2
- Molecular Weight:296.15
![2,6-Dichlorophenol](/CAS/GIF/87-65-0.gif)
87-65-0
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$10.00/10 g
![Chloroacetyl chloride](/CAS/GIF/79-04-9.gif)
79-04-9
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$12.00/5g
![Aniline](/CAS/GIF/62-53-3.gif)
62-53-3
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$10.00/1g
![Diclofenac Related Compound 7](/CAS/20210111/GIF/146607-19-4.gif)
146607-19-4
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Yield: 91%
Reaction Conditions:
Stage #1:chloroacetyl chloride;aniline in benzene at 20; for 3 h;Reflux;
Stage #2:2,6-Dichlorophenol with sodium carbonate in benzene at 80; for 24 h;Temperature;
Steps:
1.1 Preparation of 2-(2,6-dichlorophenoxy)-N-phenylacetamide (Compound II)
Chloroacetyl chloride (122 g, 1.08 mol) was added dropwise to the reaction solution under stirring at 20 ° C, and the reaction was refluxed for 3 hours (10 g, 1.07 mol), benzene (626.5 g, 8.02 mol) (127 g, 1.63 mol) was added to the reaction solution, 19 g of a catalyst (PEG-400), 2,6-dichlorophenol (175 g, 1.07 mol), sodium carbonate (78 g, 0.74 mol) (Compound II: 2- (2,6-dichlorophenoxy) - (2-methyl-2- (2,6-dichlorophenoxy) - 2-methyl-2- N-phenylacetamide) in 91% yield.
References:
Jilin University;Liaoyuan Yinying Pharmaceutical Co., Ltd.;Li Guiying;Wang Zhaokun;Li Shumei;Peng Xiaojuan;Jin Xingtong CN106905178, 2017, A Location in patent:Paragraph 0021; 0037-0039