ChemicalBook CAS DataBase List diethyl 2-acetamido-2-phenethyl-propanedioate

diethyl 2-acetamido-2-phenethyl-propanedioate synthesis

6synthesis methods

Product Name:diethyl 2-acetamido-2-phenethyl-propanedioate
CAS Number:5463-92-3
Molecular formula:C17H23NO5
Molecular Weight:321.38

DIETHYL 2-ACETAMIDO-2-(BENZOYLMETHYL)-MALONATE

15121-91-2
4 suppliers
$144.00/50mg

diethyl 2-acetamido-2-phenethyl-propanedioate

5463-92-3
47 suppliers
$215.25/250mg

Yield: 72.1%

Reaction Conditions:

with perchloric acid;palladium on activated charcoal;hydrogen in ethanol;water

Steps:

1.c c. Synthesis of 2-acetylamino-2-phenethylmalonic acid diethyl ester (Compound 15):
10.0 g of compound 14 was dissolved in ethanol (100 mL),Add 1.0 g of palladium-carbon and 0.1 mL of aqueous perchloric acid.Medium pressure hydrogenation reaction for 48-72 hours.After the reaction is completed, it is filtered through celite and the reaction solution is distilled off.The crude compound 15 obtained. The crude product was recrystallized using 50% methanol-water.The crystals were crystallized in an ice bath for 2 hours and filtered to obtain purified compound 15, with a yield of 72.1%.

References:

Chinese Academy Of Medical Sciences Pharmaceutical Institute;Shi Zeyu;Chen Si;Xiao Qiong;Zhang Xiang;Tian Yulin;Yin Dali CN111087357, 2020, A Location in patent:Paragraph 0064-0066; 0069

103-63-9 Synthesis