DIHYDROMETHYSTICIN synthesis

Yield:-

Reaction Conditions:

palladium in tetrahydrofuran;

Steps:

3 EXAMPLE 3

EXAMPLE 3 Dihydromethysticin is synthesised essentially as follows. 10% Palladium on carbon (0.03 wt. eq.) is added to a 1M solution of methysticin (1 eq.) in tetrahydrofuran. The mixture is subjected to hydrogenation using a Parr apparatus at ca. 35 p.s.i. The mixture is filtered and the combined filtrates are concentrated (in vacuo, rotovap) to give a solid. The solid material is recrystallized (ⁱPrOH) to give the desired product, whose identity is confirmed by various means including proton nuclear magnetic resonance spectrometry and mass spectrometry.

References:

US2002/192241,2002,A1 US2003/181515,2003,A1 US2002/187169,2002,A1