DiMethyl 5-(N-MethylMethylsulfonaMido)isophthalate synthesis
- Product Name:DiMethyl 5-(N-MethylMethylsulfonaMido)isophthalate
- CAS Number:695215-93-1
- Molecular formula:C12H15NO6S
- Molecular Weight:301.32
Yield: 100%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
1.b; A
First of all 2.5 g (8.7 mmol) mmol) methyl iodide were added to a solution of 0.7 g (17.4 mmol) sodium hydride (60% in mineral oil) in 10 ml DMF. The reaction solution was stirred for 2 h at ambient temperature, combined with 100 ml of water and extracted with ethyl acetate. The combined organic phases were dried and evaporated to dryness using the rotary evaporator. Quantitative yield of 1-b as a yellow oil. ES-MS (M+NH4)+=319
References:
Boehringer Ingelheim International GmbH US2006/223759, 2006, A1 Location in patent:Page/Page column 132-133; 141-142
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