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(E)-Methyl 3-(3,5-Difluorophenyl)Acrylate synthesis

5synthesis methods
-

Yield:705250-75-5 99%

Reaction Conditions:

with caesium carbonate in acetone at 65; for 1.5 h;

References:

Vu, An T.;Cohn, Stephen T.;Zhang, Puwen;Kim, Callain Y.;Mahaney, Paige E.;Bray, Jenifer A.;Johnston, Grace H.;Koury, Elizabeth J.;Cosmi, Scott A.;Deecher, Darlene C.;Smith, Valerie A.;Harrison, James E.;Leventhal, Liza;Whiteside, Garth T.;Kennedy, Jeffrey D.;Trybulski, Eugene J. [Journal of Medicinal Chemistry,2010,vol. 53,# 5,p. 2051 - 2062] Location in patent:experimental part