![](/CAS/GIF/114899-77-3.gif)
ecteinascidin 743 synthesis
- Product Name:ecteinascidin 743
- CAS Number:114899-77-3
- Molecular formula:C39H43N3O11S
- Molecular Weight:761.84
![Ecteinascidin 770](/CAS/20180808/GIF/114899-80-8.gif)
114899-80-8
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![ecteinascidin 743](/CAS/GIF/114899-77-3.gif)
114899-77-3
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$1000.00/5mg
Yield:114899-77-3 95%
Reaction Conditions:
with silver nitrate in water;acetonitrile at 20; for 24 h;Inert atmosphere;
Steps:
19 Example 19, Synthesis of Et-743
Compound 29 (7.7 mg, 0.01 mmol) was dissolved in 1 mL of acetonitrile in proportion, under argon.AgNO3 (32.3 mg, 0.19 mmol) was added to the mixed solvent of water, and the reaction was stirred at room temperature for 24 h.Add 1 mL of saturated sodium chloride and saturated sodium bicarbonate solution for 10 min.It was extracted with ethyl acetate three times, and the organic phases were combined, dried over anhydrous sodium sulfate and filtered.The solvent was removed by distillation under reduced pressure, flash column chromatography (DCM / MeOH = 20: 1), to give the compound 31 7.2mg (Et-743).The yield was 95%.
References:
CN109912629,2019,A Location in patent:Paragraph 0301-0305
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114899-77-3
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114899-77-3
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![ecteinascidin 743](/CAS/GIF/114899-77-3.gif)
114899-77-3
145 suppliers
$1000.00/5mg