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ChemicalBook CAS DataBase List Emtricitabine Impurity 8
64282-88-8

Emtricitabine Impurity 8 synthesis

5synthesis methods
-

Yield:83 % ee

Reaction Conditions:

with D-glucose;(-)-menthone:(-)-menthol reductase;glucose dehydrogenase from Pseudomonas sp;nicotinamide adenine dinucleotide phosphate in ethanol at 25; pH=7; for 10 h;Kinetics;Enzymatic reaction;Overall yield = 18 %Chromat.;

References:

Lygidakis, Antonios;Karuppiah, Vijaykumar;Hoeven, Robin;Ní Cheallaigh, Aisling;Leys, David;Gardiner, John M.;Toogood, Helen S.;Scrutton, Nigel S. [Angewandte Chemie - International Edition,2016,vol. 55,# 33,p. 9596 - 9600][Angew. Chem.,2016,vol. 128,p. 9748 - 9752] Location in patent:supporting information

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