Endoxifen (hydrochloride) synthesis
- Product Name:Endoxifen (hydrochloride)
- CAS Number:1197194-41-4
- Molecular formula:C25H28ClNO2
- Molecular Weight:409.95
611-99-4
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: zinc; titanium tetrachloride / tetrahydrofuran / 12 h / -20 °C / Inert atmosphere; Reflux; Darkness
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / Reflux
2.2: 7 h / 120 °C
3.1: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 12.5 h / 0 °C / Reflux
3.2: 3 h / Reflux
References:
Ding, Song;Qiao, Xin;Kucera, Gregory L.;Bierbach, Ulrich [Chemical Communications,2013,vol. 49,# 24,p. 2415 - 2417]
68392-35-8
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93-55-0
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$15.00/25g
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91221-46-4
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$68.00/2 mg
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