ChemicalBook CAS DataBase List N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) synthesis

12synthesis methods

Product Name:N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
CAS Number:110025-28-0
Molecular formula:C25H27NO2
Molecular Weight:373.49

611-99-4 Synthesis

611-99-4
429 suppliers
$6.00/5g

N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

110025-28-0
66 suppliers
$36.00/1mg

Yield:-

Steps:

Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 0 - 60 °C
2: zinc; titanium tetrachloride / tetrahydrofuran / 2.5 h / 0 °C / Inert atmosphere; Reflux
3: potassium carbonate / acetonitrile / 24 h / 80 °C
4: methanol; water / 16 h / 80 °C / Sealed tube
5: boron tribromide / dichloromethane / 0.5 h / -78 °C

References:

EISAI R&D MANAGEMENT CO., LTD.;HAO, Ming-Hong;KORPAL, Manav;NYAVANANDI, Vijay Kumar;PUYANG, Xiaoling;SAMAJDAR, Susanta;SMITH, Peter Gerard;WANG, John;ZHENG, Guo Zhu;ZHU, Ping WO2016/196342, 2016, A1

74-89-5 Synthesis