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ChemicalBook CAS DataBase List Tamoxifen Citrate EP Impurity C
19957-51-8

Tamoxifen Citrate EP Impurity C synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: NaH / dimethylformamide / 0.25 h / 60 °C
2: 1.) n-butyllithium, 2.) acetaldehyde / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C to 0 deg C, 20 min

References:

Foster;Jarman;Leung;McCague;Leclercq;Devleeschouwer [Journal of Medicinal Chemistry,1985,vol. 28,# 10,p. 1491 - 1497]

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