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ChemicalBook CAS DataBase List Esomeprazole magnesium
161973-10-0

Esomeprazole magnesium synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: dihydrogen peroxide / bis(acetylacetonate)oxovanadium / water; acetone / 3.5 h / 10 - 15 °C
2: dichloromethane; toluene / 4.25 h / 20 °C
3: toluene; water / 1 h / 35 - 40 °C
4: acetone; methanol / 2.5 h / 20 °C

References:

WO2012/104863,2012,A2

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