Ethanone, 2,2-bis(acetyloxy)-1-phenyl- synthesis
- Product Name:Ethanone, 2,2-bis(acetyloxy)-1-phenyl-
- CAS Number:5062-30-6
- Molecular formula:C12H12O5
- Molecular Weight:236.22
13665-04-8
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Yield: 98%
Reaction Conditions:
with silver(I) acetate in acetonitrile at 70; for 15 h;Inert atmosphere;Darkness;
Steps:
General procedure for acetoxylation of alkyl halides with AgOAc.
General procedure: To a suspension of AgOAc (0.25 mmol) in MeCN or DMF (2 mL) was added the alkylhalide (0.25 mmol) dissolved in 1 mL of the corresponding solvent. The reaction mixture was stirred at the temperature indicated on table 1 until starting material was consumed. After that, a saturated solution of NH4Cl (20 mL) was added and the crude mixture was extracted three times with EtOAc (3 x 15 mL). When necessary, the product was purifiedby column chromatography (hexane/EtOAc).
References:
Nolla-Saltiel, Roberto;Carrillo-Arcos, Ulises Alonso;Porcel, Susana [Synthesis,2014,vol. 46,# 2,p. 165 - 169] Location in patent:supporting information