![](/CAS/GIF/68809-64-3.gif)
ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate synthesis
- Product Name:ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate
- CAS Number:68809-64-3
- Molecular formula:C8H12N2O2
- Molecular Weight:168.19
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
736 suppliers
$9.00/25ml
![1H-Pyrazole-5-carboxylic acid, 4-methyl-, ethyl ester](/CAS/GIF/856061-38-6.gif)
856061-38-6
16 suppliers
inquiry
![ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate](/CAS/GIF/68809-64-3.gif)
68809-64-3
23 suppliers
$220.00/100mg
Yield:68809-64-3 76.38%
Reaction Conditions:
with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 0 - 25; for 5 h;Inert atmosphere;
Steps:
206.1 Step 1: ethyl l,4-dimethyl-lH-pyrazole-5-carboxylate
Into a 100-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed ethyl 4-methyl-lH-pyrazole-5-carboxylate (3 g, 19.46 mmol, 1 equiv.), DIAD (7.9 g, 38.92 mmol, 2 equiv.), THF (30 mL), and MeOH (3.1 g, 97.30 mmol, 5 equiv.), and ΡΡ1 (10.2 g, 38.92 mmol, 2 equiv.) was added at 0 °C. The resulting solution was stirred for 5 h at 25°C and then concentrated under vacuum. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1 :50) to give the title compound as a yellow liquid in76.38% yield.
References:
WO2019/18562,2019,A1 Location in patent:Paragraph 0695
![1H-Pyrazole-5-carboxylic acid, 4-methyl-, ethyl ester](/CAS/GIF/856061-38-6.gif)
856061-38-6
16 suppliers
inquiry
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
340 suppliers
$15.00/10g
![ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate](/CAS/GIF/68809-64-3.gif)
68809-64-3
23 suppliers
$220.00/100mg
![1H-Pyrazole-5-carboxylic acid, 4-methyl-, ethyl ester](/CAS/GIF/856061-38-6.gif)
856061-38-6
16 suppliers
inquiry
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
340 suppliers
$15.00/10g
![ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate](/CAS/GIF/68809-64-3.gif)
68809-64-3
23 suppliers
$220.00/100mg
![ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate](/CAS/GIF/68809-65-4.gif)
68809-65-4
31 suppliers
$130.00/50mg
![(E)-1,1,1-trichloro-4-ethoxy-3-methylbut-3-en-2-one](/CAS/20180601/GIF/121781-57-5.gif)
121781-57-5
6 suppliers
inquiry
![ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate](/CAS/GIF/68809-64-3.gif)
68809-64-3
23 suppliers
$220.00/100mg