ETHYL 1-HYDROXYCYCLOHEXANE-CARBOXYLATE synthesis
- Product Name:ETHYL 1-HYDROXYCYCLOHEXANE-CARBOXYLATE
- CAS Number:1127-01-1
- Molecular formula:C9H16O3
- Molecular Weight:172.22
Yield: 88.6%
Reaction Conditions:
Stage #1:1-hydroxy-1-cyclohexanecarbonitrile;ethanol with hydrogenchloride at 0 - 25; for 14 h;
Stage #2: with water at 20;
Steps:
2.1 1. Synthesis of ethyl hydroxycyclohexanecarboxylate
Add 375 g (3 mol) of cyclohexanonitrile to the reaction flask. And 2400 mL of ethanol, Cool down to -10 °C in a low temperature cold bath, 110 g (3.0 mol) of hydrogen chloride gas was introduced to reach saturation. Stirring at 0 ° C for 2 h, then heating to 20 ~ 25 ° C, The reaction was stirred for 12 h, and after the reaction was completed, the ethanol was distilled off. The residue was dissolved in 500 mL of water, and stirred at room temperature for 1.5 to 2 hours for hydrolysis. Toluene 300mL × 3 extractions, Toluene layer drying After desolvation, 475.2 g of pale yellow liquid ethyl hydroxycyclohexanoate was obtained. The yield was 88.6%.
References:
Shandong Kangqiao Biological Technology Co., Ltd.;Xiang Xiaozhong;Sheng Guozhu;Zhu Qingbo;Li Ning;Zhang Zihan CN108840846, 2018, A Location in patent:Paragraph 0006; 0011; 0035-0037
1123-28-0
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1127-01-1
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1127-01-1
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1123-28-0
113 suppliers
$16.00/250mg
1127-01-1
92 suppliers
$22.00/1g