ETHYL 1-HYDROXYCYCLOPENTANE-CARBOXYLATE synthesis

Yield:41248-23-1 95%

Reaction Conditions:

with sulfuric acid at 20; for 72 h;

Steps:

Ethyl 1-hydroxycyclopentanecarboxylate

To a solution of 1-hydroxycyclopentanecarboxylic acid (0.98 g, 7.5 mmol) in ethanol (3.8 ml) was added a cat amount of sulfuric acid. The reaction mixture was stuffed for 3 d at room temperature. The solvent was concentrated in vacuo. The residue was partitioned between ethyl acetate (75-ml) and brine (25-ml). The layers were separated. The aqueous layer wasextracted with one 75-ml portion of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound (1.13 g, 95%) as light brown oil. MS mle: 159 ([M+H]j

References:

WO2015/124541,2015,A1 Location in patent:Page/Page column 81