ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE synthesis
1synthesis methods
- Product Name:ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE
- CAS Number:80120-38-3
- Molecular formula:C14H18O3
- Molecular Weight:234.3
Yield:80120-38-3 98%
Reaction Conditions:
Stage #1: 1-chloro-2,3,5,6-tetramethylbenzenewith naphthalene;lithium in diethyl ether at 3 - 6; for 3 h;
Stage #2: with copper(l) cyanide in tetrahydrofuran;diethyl ether at 3 - 6; for 0.5 h;
Stage #3: Ethyl oxalyl chloride in tetrahydrofuran;diethyl ether at 3 - 20; for 1.33333 h;Cooling with ice;
References:
Screttas, Constantinos G.;Steele, Barry R.;Micha-Screttas, Maria;Heropoulos, Georgios A. [Organic Letters,2012,vol. 14,# 22,p. 5680 - 5683] Location in patent:supporting information