Ethyl 2-(4-Oxocyclohexyl)propanoate synthesis
- Product Name:Ethyl 2-(4-Oxocyclohexyl)propanoate
- CAS Number:31180-85-5
- Molecular formula:C11H18O3
- Molecular Weight:198.2588
31180-84-4
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Yield:31180-85-5 91.5%
Reaction Conditions:
with hydrogenchloride in acetone at 20; for 24 h;Concentration;
Steps:
Intermediate 27C: racemic ethyl 2-(4-oxocyclohexyl)propanoate
A racemic mixture of Intermediate 27B (17.1 g, 70.6 mmol) was dissolved in acetone (250 mL). Then 1 N aq. HC1 (62 mL) was added and the mixture was stirred at room temperature for 24 hours. The mixture was concentrated under reduced pressure and extracted with EtOAc (200 mL x 3). The combined organic extracts were washed with 1 N aq. NaOH (50 mL), dried over anhydrous MgS04, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (0-20% EtOAc in petroleum ether) to afford Intermediate 27C (12.8 g, 91.5% yield).
References:
WO2016/73770,2016,A1 Location in patent:Paragraph 0287
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