![](/CAS/GIF/32955-21-8.gif)
Ethyl 2-aminothiazole-5-carboxylate synthesis
- Product Name:Ethyl 2-aminothiazole-5-carboxylate
- CAS Number:32955-21-8
- Molecular formula:C6H8N2O2S
- Molecular Weight:172.2
Yield:32955-21-8 95.7%
Reaction Conditions:
with potassium sulfide;copper in tetrahydrofuran;water at 55; for 1.5 h;Inert atmosphere;Temperature;
Steps:
1 Example 1
A method for the synthesis of an intermediate of dasatinib,The method comprises: under nitrogen protection,Ethyl 3-ethoxyacrylate (14.4 g, 100 mmol)And urea 12 g (200 mmol)And potassium sulfide 33. lg (300 mmol) of nano-copper powder 1.4 g (10%1 OOnm) under the catalytic 55 ° C contact reaction 1.5 hours,The solvent for the contact reaction was 100 ml of a 6: 1 by volume mixture of THF and H20,Cooled to room temperature,Poured into ice water,Dichloromethane extraction,The organic phase was concentrated,Washed,Then recrystallized from ethanol,Amino-thiazole-5-carboxylic acid ethyl ester of dasatinib as an intermediate, 16.5 g,The yield was 95.7%Purity 99.34%.
References:
Qingdao Chenda Biological Technology Co., Ltd.;Chen, Linghao CN106008393, 2016, A Location in patent:Paragraph 0034; 0035
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