ethyl 2-(methylthio)-1,3-thiazole-4-carboxylate synthesis
- Product Name:ethyl 2-(methylthio)-1,3-thiazole-4-carboxylate
- CAS Number:40279-32-1
- Molecular formula:C7H9NO2S2
- Molecular Weight:203.28
41731-52-6
106 suppliers
$7.00/100mg
5188-07-8
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$13.00/5g
40279-32-1
14 suppliers
$45.00/10mg
Yield:40279-32-1 68%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 23; for 1 h;
Steps:
1 Step 1: Preparation of ethyl 2-(methylsulfanyl)-1,3-thiazole-4-carboxylate
Into a round bottom flask equipped with a magnetic stir bar was added ethyl 2-chloro-1,3-thiazole-4-carboxylate (1.0 equiv), DMF (0.9 M), K2CO3 (2 equiv) and sodium methanethiolate (1.2 equiv). The resulting mixture was stirred at 23 °C for 1 h. LC-MS analysis indicated consumption of starting material and formation of product. The resulting mixture was poured into a separatory funnel containing water (10 volumes) and the aqueous layer was extracted with ethyl acetate (3 × 2 volumes). The combined organic layers were washed with brine and dried over anhydrous Na2SO4. After filtration, the filtrate was concentrated under reduced pressure to afford the title product as a dark yellow solid (68% yield).
References:
WO2021/234547,2021,A1 Location in patent:Paragraph 000165-000166
