ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE synthesis
- Product Name:ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE
- CAS Number:89409-89-2
- Molecular formula:C16H13NO2
- Molecular Weight:251.28
Yield:89409-89-2 245 mg
Reaction Conditions:
Stage #1: 4-bromobenzenecarbonitrilewith isopropylmagnesium chloride in tetrahydrofuran at 0; for 2 h;Inert atmosphere;
Stage #2: with Zn(OPiv)2*2LiCl in tetrahydrofuran at 0; for 0.5 h;Inert atmosphere;
Stage #3: Ethyl 4-bromobenzoatewith [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride in ethyl acetate at 25; for 2 h;Inert atmosphere;Negishi coupling reaction;
References:
Bernhardt, Sebastian;Manolikakes, Georg;Kunz, Thomas;Knochel, Paul [Angewandte Chemie - International Edition,2011,vol. 50,# 39,p. 9205 - 9209] Location in patent:supporting information; experimental part
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