![](/CAS/GIF/24393-56-4.gif)
Ethyl 4-methoxycinnamate synthesis
- Product Name:Ethyl 4-methoxycinnamate
- CAS Number:24393-56-4
- Molecular formula:C12H14O3
- Molecular Weight:206.24
![Synthesis of ethyl 4-methoxycinnamate](/NewsImg/2022-08-25/6379706254798423238664591.jpg)
Synthesis of ethyl 4-methoxycinnamate
![p-Anisaldehyde](/CAS/20180808/GIF/123-11-5.gif)
123-11-5
839 suppliers
$10.00/10g
![Ethyl (triphenylphosphoranylidene)acetate](/CAS/GIF/1099-45-2.gif)
1099-45-2
361 suppliers
$6.00/5g
![Ethyl 4-methoxycinnamate](/CAS/GIF/24393-56-4.gif)
24393-56-4
214 suppliers
$5.00/250mg
Yield:24393-56-4 77%
Reaction Conditions:
in dichloromethane at 20; for 16 h;Inert atmosphere;
Steps:
(E)-Ethyl 3-(4-methoxyphenyl)acrylate.
To a stirred solution of 4-methoxybenzaldehyde (1.00 mL, 8.25 mmol) in anhydrous dichloromethane (15 mL) under Ar atmosphere was added ethyl (triphenylphosphoranylidene)acetate (3.02 g, 8.66 mmol). The mixture solution was stirred for 16 h at room temperature and then concentrated under reduced pressure. The resulting solid was purified by column chromatography on silica (20% EtOAc/hexanes) to give the desired product as a colorless oil (1.31 g, 6.34 mmol, 77%).
References:
Radomkit, Suttipol;Sarnpitak, Pakornwit;Tummatorn, Jumreang;Batsomboon, Paratchata;Ruchirawat, Somsak;Ploypradith, Poonsakdi [Tetrahedron,2011,vol. 67,# 21,p. 3904 - 3914] Location in patent:supporting information; experimental part
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623-12-1
274 suppliers
$10.00/25g
![Ethyl acrylate](/CAS/GIF/140-88-5.gif)
140-88-5
515 suppliers
$12.00/100ml
![Ethyl 4-methoxycinnamate](/CAS/GIF/24393-56-4.gif)
24393-56-4
214 suppliers
$5.00/250mg
![Triethyl phosphonoacetate](/CAS/GIF/867-13-0.gif)
867-13-0
462 suppliers
$10.00/1g
![p-Anisaldehyde](/CAS/20180808/GIF/123-11-5.gif)
123-11-5
839 suppliers
$10.00/10g
![Ethyl 4-methoxycinnamate](/CAS/GIF/24393-56-4.gif)
24393-56-4
214 suppliers
$5.00/250mg
![p-Anisaldehyde](/CAS/20180808/GIF/123-11-5.gif)
123-11-5
839 suppliers
$10.00/10g
![Ethyl bromoacetate](/CAS/GIF/105-36-2.gif)
105-36-2
348 suppliers
$5.00/5 g
![Ethyl 4-methoxycinnamate](/CAS/GIF/24393-56-4.gif)
24393-56-4
214 suppliers
$5.00/250mg
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
706 suppliers
$10.00/50g
![4-METHOXYCINNAMIC ACID](/CAS/GIF/943-89-5.gif)
943-89-5
170 suppliers
$19.89/10g
![Ethyl 4-methoxycinnamate](/CAS/GIF/24393-56-4.gif)
24393-56-4
214 suppliers
$5.00/250mg