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104092-78-6

ETHYL 7-OXONONANOATE synthesis

3synthesis methods
-

Yield:-

Reaction Conditions:

with sulfuric acid for 15 h;Heating / reflux;

Steps:



A mixture comprising 500 ml of ethanol and 5.5 ML of concentrated sulfuric acid, was added to 43.1 g of the crude 7-oxononanoic acid, and the mixture was reacted for 15 hours under reflux. After completion of the reaction, ethanol was distilled off under reduced pressure, and diethyl ether was added, followed by washing three times with water and once with a saturated sodium chloride aqueous solution. It was dried over anhydrous sodium sulfate, and diethyl ether was distilled off under reduced pressure to obtain 47.8 g of crude ethyl 7- oxononanate.

References:

WO2004/52872,2004,A1 Location in patent:Page 63-64

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