ChemicalBook CAS DataBase List ETHYL BENZOFURAZAN-5-CARBOXYLATE

ETHYL BENZOFURAZAN-5-CARBOXYLATE synthesis

7synthesis methods

Product Name:ETHYL BENZOFURAZAN-5-CARBOXYLATE
CAS Number:36389-07-8
Molecular formula:C9H8N2O3
Molecular Weight:192.17

64-17-5 Synthesis

64-17-5
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54286-62-3 Synthesis

54286-62-3
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36389-07-8
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Yield:36389-07-8 75%

Reaction Conditions:

with sulfuric acid for 14 h;Reflux;

Steps:

To a solution of benzo[c][l,2,5]oxadiazole-5-carbonitrile (700 mg, 1.33 mol) in EtOH (100 mL) was added H₂SC^ (20 mL) and the reaction mixture was refluxed for 14 h. The reaction was concentrated in vacuo and the residue was diluted with water (50 mL), and extracted with DCM (2 x 100 mL). The combined organic layers were dried over magnesium sulfate, filtered, and then concentrated in vacuo to afford ethyl benzo[c][l,2,5]oxadiazole-5-carboxylate (0.7 g, 75%) as a yellow, sticky solid.

References:

WO2009/158393,2009,A1 Location in patent:Page/Page column 101