ETHYL ISOAMYLACETOACETATE synthesis
- Product Name:ETHYL ISOAMYLACETOACETATE
- CAS Number:84389-67-3
- Molecular formula:C11H20O3
- Molecular Weight:200.27
2033-24-1
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84389-67-3
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Yield:84389-67-3 99%
Reaction Conditions:
Stage #1: cycl-isopropylidene malonate;5-methylhexanoic acidwith dmap;dicyclohexyl-carbodiimide in dichloromethane at 20;
Stage #2: ethanolHeating / reflux;
Steps:
43.A
To a stirred solution of Meldrum's Acid (2.0 g, 13.9 mmol) in 100 mL of CH2CI2, hexanoic acid (1.61 g, 13.9 mmol) was added followed by DMAP (3.39 g, 27.8 mmol) and finally DCC (2.86 g, 13.9 mmol). The reaction stirred overnight at room temperature. The mixture was then filtered and the filtrate washed with 1 M HCl, H20 and Brine. The organics were then dried over sodium sulfate, filtered and concentrated to a yellow oil. The material was then dissolved in 100 mL of EtOH and refluxed overnight. The reaction mixture was concentrated to yield 2.58 g (99%) of a clear oil. No purification performed : lH NMR (CDC13, 400 MHz) 8 4.22-4. 12 (q, 2H, J= 7. 07), 3.40 (s, 2H), 2.56-2. 44 (t, 2H, J = 7. 42), 1.69-1. 43 (m, 3H), 1.30-1. 21 (t, 3H, J= 7. 07), 1.19-1. 09 (m, 2H), 0.89-0. 81 (d, 6H, J = 6. 55).
References:
WO2003/76440,2003,A1 Location in patent:Page/Page column 111-112
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84389-67-3
18 suppliers
$154.00/1g
628-46-6
78 suppliers
$27.00/5g
84389-67-3
18 suppliers
$154.00/1g
5699-78-5
7 suppliers
inquiry
84389-67-3
18 suppliers
$154.00/1g