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18588-57-3

Etoprine synthesis

3synthesis methods
3218-49-3 Synthesis
3,4-Dichlorophenylacetonitrile

3218-49-3
257 suppliers
$5.00/5g

Etoprine

18588-57-3
3 suppliers
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: LDA / tetrahydrofuran / 0.17 h / -78 °C
1.2: tetrahydrofuran / -78 °C
2.1: dioxane / 20 °C
3.1: dimethylsulfoxide / 0.08 h / 80 °C

References:

Tarnchompoo, Bongkoch;Sirichaiwat, Chawanee;Phupong, Worrapong;Intaraudom, Chakapong;Sirawaraporn, Worachart;Kamchonwongpaisan, Sumalee;Vanichtanankul, Jarunee;Thebtaranonth, Yodhathai;Yuthavong, Yongyuth [Journal of Medicinal Chemistry,2002,vol. 45,# 6,p. 1244 - 1252]

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