6-ETHYLPYRIMIDIN-4-AMINE synthesis
- Product Name:6-ETHYLPYRIMIDIN-4-AMINE
- CAS Number:856160-67-3
- Molecular formula:C6H9N3
- Molecular Weight:123.16
1263400-54-9
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856160-67-3
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Yield:856160-67-3 92%
Reaction Conditions:
with 20% palladium hydroxide-activated charcoal;hydrogen in methanol at 20 - 25; for 21.25 h;
Steps:
6-Ethylpyrimidin-4-amine
[00301j A solution of 6-vinylpyrimidin-4-amine (prepared according to the procedure of PCT Patent Application WO 20 12/035039, Example 8, Step 2; 100 mg, 0.825 mmol) in methanol (5 mL) was treated with 20% palladium hydroxide on carbon (50 mg, 0.07 1 mmol). The mixture was stirred at room temperature under a hydrogen atmosphere for 21.25 h. The mixture was filtered through CELITE, the solids were rinsed withmethanol and the combined filtrates were concentrated under vacuum to provide 6- ethylpyrimidin-4-amine as a white waxy solid (94 mg, 92% yield). ‘H NMR (400 MHz,DMSO-d6) ? 8.25 (d, J=1.1 Hz, 1H), 6.65 (br. s., 2H), 6.29 - 6.19 (m, 1H), 2.46 (q, J=7.6 Hz, 2H), 1.14 (t, J=7.6 Hz, 3H)
References:
WO2014/74661,2014,A1 Location in patent:Paragraph 00301
141602-25-7
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856160-67-3
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15043-03-5
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856160-67-3
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6554-65-0
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856160-67-3
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