ChemicalBook CAS DataBase List Fesoterodine Related Impurity 4

Fesoterodine Related Impurity 4 synthesis

9synthesis methods

Product Name:Fesoterodine Related Impurity 4
CAS Number:214601-12-4
Molecular formula:C22H29NO2
Molecular Weight:339.47

(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol

214601-54-4
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214601-12-4
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Yield:-

Reaction Conditions:

with hydrogen;5%-palladium/activated carbon in methanol at 25 - 30; under 2206.72 - 2942.29 Torr; for 8 h;autoclave;

Steps:

33

Example-33: Preparation of (R)-N,N-diisopropyl-3-(5-formyl-2-hydroxyphenyl)-3- phenyl propanamine compound of formula-ll(R)-4-(benzyloxy)-3 -(3 -(diisopropylamino)- 1 -phenylpropyl) benzaldehyde (20 gm), methanol (200 ml) and 5% Pd/C (10 gm) were charged into an autoclave at 25- 30°C under nitrogen atmosphere. 3-4 Kg/Cm² hydrogen gas pressure was applied to the reaction mixture for 8 hrs at 25-30°C. After the completion of the reaction, filtered the reaction mixture through hyflow bed and washed with methanol. Distilled off the solvent completely form the filtrate under reduced pressure to get the title compound. Yield: 14 gm;

References:

WO2012/98560,2012,A2 Location in patent:Page/Page column 66

123-08-0 Synthesis