FGTI-2734 synthesis

Yield:1247018-19-4 81%

Reaction Conditions:

Stage #1: N-(2-(4-cyano-2-fluorophenylamino)ethyl)-N-(cyclohexylmethyl)pyridine-2-sulfonamidewith sodium hydride in N,N-dimethyl-formamide at 0; for 0.25 h;Inert atmosphere;
Stage #2: 5-chloromethyl-1-methyl-1H-imidazole hydrochloride in N,N-dimethyl-formamide at 0;Inert atmosphere;

References:

Fletcher, Steven;Keaney, Erin Pusateri;Cummings, Christopher G.;Blaskovich, Michelle A.;Hast, Michael A.;Glenn, Matthew P.;Chang, Sung-Youn;Bucher, Cynthia J.;Floyd, Ryan J.;Katt, William P.;Gelb, Michael H.;Van Voorhis, Wesley C.;Beese, Lorena S.;Sebti, Said M.;Hamilton, Andrew D. [Journal of Medicinal Chemistry,2010,vol. 53,# 19,p. 6867 - 6888] Location in patent:experimental part