ChemicalBook CAS DataBase List Fingolimod Impurity 8

Fingolimod Impurity 8 synthesis

6synthesis methods

Product Name:Fingolimod Impurity 8
CAS Number:162358-96-5
Molecular formula:C16H25I
Molecular Weight:344.27

629-04-9 Synthesis

629-04-9
345 suppliers
$7.00/10g

162358-96-5
14 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 9 steps
1.1: Mg / tetrahydrofuran / 1 h / 40 °C
1.2: 49 percent / tetrahydrofuran / 1 h / 20 °C
2.1: 82 percent / P₂O₅ / benzene / 2 h / Heating
3.1: Mg / tetrahydrofuran / 0.5 h / 50 °C
3.2: 88 percent / tetrahydrofuran / 15 h / 20 °C
4.1: 82 percent / H₂ / 5percent Pd/C / ethanol / 4 h
5.1: Triton B / methanol; dioxane / 2 h / 80 °C
6.1: HCl / 0.5 h / 20 °C
7.1: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C
8.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C
9.1: NaI / butan-2-one / 2 h / Heating

References:

Kiuchi, Masatoshi;Adachi, Kunitomo;Kohara, Toshiyuki;Minoguchi, Masanori;Hanano, Tokushi;Aoki, Yoshiyuki;Mishina, Tadashi;Arita, Masafumi;Nakao, Noriyoshi;Ohtsuki, Makio;Hoshino, Yukio;Teshima, Koji;Chiba, Kenji;Sasaki, Shigeo;Fujita, Tetsuro [Journal of Medicinal Chemistry,2000,vol. 43,# 15,p. 2946 - 2961]