ChemicalBook CAS DataBase List FRAX1036

FRAX1036 synthesis

10synthesis methods

Product Name:FRAX1036
CAS Number:1432908-05-8
Molecular formula:C28H32ClN7O
Molecular Weight:518.05

849934-94-7 Synthesis

Methyl 2-(4-broMo-2-chlorophenyl)acetate

849934-94-7
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$26.00/1g

1432908-05-8
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$41.00/1mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / Inert atmosphere; Reflux
2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water; toluene / 100 °C / Inert atmosphere
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 20 °C / Inert atmosphere
4: N,N-dimethyl-formamide / 48 h / 85 °C / Inert atmosphere

References:

Koval, Alexander B.;Wuest, William M. [Tetrahedron Letters,2016,vol. 57,# 3,p. 449 - 451]

849934-95-8 Synthesis