FTI-2153 synthesis
- Product Name:FTI-2153
- CAS Number:344900-92-1
- Molecular formula:C25H30N4O3S
- Molecular Weight:466.6
![(S)-methyl 2-(5-(aminomethyl)-2-methyl-[1,1-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate(WXG00310)](/CAS/20210111/GIF/722454-00-4.gif)
Yield:344900-92-1 54%
Reaction Conditions:
Stage #1: 2-[(5-aminomethyl-2'-methylbiphenyl-2-carbonyl)amino]-4-methylsulfanylbutyric acid methyl ester;4(5)formylimidazole in methanol at 20; for 0.5 h;
Stage #2: with sodium tetrahydroborate in methanol; for 36 h;
References:
Carrico, Dora;Ohkanda, Junko;Kendrick, Howard;Yokoyama, Kohei;Blaskovich, Michelle A.;Bucher, Cynthia J.;Buckner, Frederick S.;Van Voorhis, Wesley C.;Chakrabarti, Debopam;Croft, Simon L.;Gelb, Michael H.;Sebti, Sa?d M.;Hamilton, Andrew D. [Bioorganic and Medicinal Chemistry,2004,vol. 12,# 24,p. 6517 - 6526]
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