![](/CAS/GIF/126-07-8.gif)
(+)-Griseofulvin synthesis
- Product Name:(+)-Griseofulvin
- CAS Number:126-07-8
- Molecular formula:C17H17ClO6
- Molecular Weight:352.77
![2-chloro-3,5-dimethoxyphenol(WXC05665)](/CAS/20200611/GIF/18113-21-8.gif)
18113-21-8
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![(+)-Griseofulvin](/CAS/GIF/126-07-8.gif)
126-07-8
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Yield:-
Steps:
Multi-step reaction with 12 steps
1: 93 percent / pyridine
2: 94 percent / AlCl3 / chlorobenzene / 0.5 h / Heating
3: 73 percent / diisopropylazodicarboxylate, tributylphosphine
4: 78 percent / LHMDS / tetrahydrofuran / -78 °C
5: 95 percent / MsN3, Et3N
6: 62 percent / 5 mol percent of rhodium pivalate
7: 1.) O3, 2.) DMS / 1.) CH2Cl2, MeOH
8: tetrahydrofuran / Ambient temperature
9: 100 percent / TFA
10: 1.) diphenyl phosphorazidate, Et3N, 2.) aq. HCl / 1.) toluene, reflux, 2.) reflux, 2 h
11: 49 percent / NaOMe / methanol / Ambient temperature
12: 95 percent / tetrahydrofuran / Ambient temperature
References:
Pirrung;Brown;Rege;Laughton [Journal of the American Chemical Society,1991,vol. 113,# 22,p. 8561 - 8562]
![Ethanone, 1-(3-chloro-2-hydroxy-4,6-dimethoxyphenyl)-](/CAS/20180601/GIF/81325-85-1.gif)
81325-85-1
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![(+)-Griseofulvin](/CAS/GIF/126-07-8.gif)
126-07-8
515 suppliers
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![Phenol, 2-chloro-3,5-dimethoxy-, 1-acetate](/CAS/20210305/GIF/131939-10-1.gif)
131939-10-1
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![(+)-Griseofulvin](/CAS/GIF/126-07-8.gif)
126-07-8
515 suppliers
$5.00/25mg
![Ethanone, 1-[3-chloro-4,6-dimethoxy-2-[(1-methyl-2-butenyl)oxy]phenyl]-, [S-(E)]- (9CI)](/CAS/20210305/GIF/136616-28-9.gif)
136616-28-9
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![(+)-Griseofulvin](/CAS/GIF/126-07-8.gif)
126-07-8
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$5.00/25mg
![Benzenepropanoic acid, 3-chloro-4,6-dimethoxy-2-[(1-methyl-2-butenyl)oxy]-β-oxo-, methyl ester, [S-(E)]- (9CI)](/CAS/20210305/GIF/136616-29-0.gif)
136616-29-0
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![(+)-Griseofulvin](/CAS/GIF/126-07-8.gif)
126-07-8
515 suppliers
$5.00/25mg