![](/CAS/GIF/19883-41-1.gif)
H-D-PHG-OME HCL synthesis
- Product Name:H-D-PHG-OME HCL
- CAS Number:19883-41-1
- Molecular formula:C9H12ClNO2
- Molecular Weight:201.65
Yield:19883-41-1 98.9%
Reaction Conditions:
with dichlorosulfoxide at 0 - 75; for 2 h;
Steps:
First step
General procedure: The methyl-esterification reaction of L-phenylalanine.To a suspension of L-phenylalanine (1 g, 6.05 mmol, 1.0 equiv) inmethanol (25 mL) cooled to 0 C was added thionyl chloride(475 mL, 6.66 mmol, 1.5 equiv) slowly. After 10 min, the reactionmixture was heated to 75 C to reflux for 2 h. After completion(monitored by TLC), the solvent was removed in vacuo, and at thistime, a white solid was formed methyl L-phenylalaninate hydrochloride(1.23 g, quantitative yield).
References:
Liu, Sha;Jing, Li;Yu, Zhu-Jun;Wu, Chengyong;Zheng, Yongxiang;Zhang, En;Chen, Qiang;Yu, Yamei;Guo, Li;Wu, Yong;Li, Guo-Bo [European Journal of Medicinal Chemistry,2018,vol. 145,p. 649 - 660]
![Phenylboronic acid](/CAS/GIF/98-80-6.gif)
98-80-6
713 suppliers
$5.00/5g
![H-D-PHG-OME HCL](/CAS/GIF/19883-41-1.gif)
19883-41-1
334 suppliers
$6.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$9.00/25ml
![Boc-D-Phenylglycine](/CAS/GIF/33125-05-2.gif)
33125-05-2
323 suppliers
$11.19/5G
![H-D-PHG-OME HCL](/CAS/GIF/19883-41-1.gif)
19883-41-1
334 suppliers
$6.00/5g
![methyl 2-amino-2-phenylacetate hydrochloride](/CAS/20150408/GIF/15028-40-7.gif)
15028-40-7
61 suppliers
$9.00/1g
![H-PHG-OME HCL](/CAS/GIF/15028-39-4.gif)
15028-39-4
203 suppliers
$5.00/1g
![H-D-PHG-OME HCL](/CAS/GIF/19883-41-1.gif)
19883-41-1
334 suppliers
$6.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$9.00/25ml
![D-2-Phenylglycine](/CAS/GIF/875-74-1.gif)
875-74-1
410 suppliers
$6.00/10g
![H-PHG-OME HCL](/CAS/GIF/15028-39-4.gif)
15028-39-4
203 suppliers
$5.00/1g
![H-D-PHG-OME HCL](/CAS/GIF/19883-41-1.gif)
19883-41-1
334 suppliers
$6.00/5g