HEPTANOICACIDHYDRAZIDE synthesis

6synthesis methods

Product Name:HEPTANOICACIDHYDRAZIDE
CAS Number:22371-32-0
Molecular formula:C7H16N2O
Molecular Weight:144.21

106-73-0 Synthesis

106-73-0
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22371-32-0
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Yield:22371-32-0 80%

Reaction Conditions:

with hydrazine hydrate monohydrate in methanol; for 6 h;Reflux;

Steps:

1 Synthesis of heptanoic acid hydrazide

The methyl heptanoate (lOg, 0.06 mol) was dispersed in a mixture of methanol (140 mL) and hydrazine monohydrate (21 mL, 0.6 mol) (Al- Amiery, A. A.; Kassim, F. A. B.; Kadhum, A. A. H.; Mohamad, A. B. Synthesis and characterization of a novel eco-friendly corrosion inhibition for mild steel in 1 M hydrochloric acid. Scientific Reports 2016, 6, 19890; Poolman, J. M.; Maity, C.; Boekhoven, L; Mee, L. v. d.; Sage, V. A. A. L; Groenewold, G. J. M.; Kasteren, S. I. v.; Versluis, F.; Esch, J. H. v.; Eelkema, R. A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels. J. Mater. Chem. B 2016, 4, 852-859; Cougnon, F. B. L.; Caprice, K.; Pupier, M.; Bauza, A.; Frontera, A. A Strategy to Synthesize Molecular Knots and Links Using the Hydrophobic Effect. J. Am. Chem. Soc. 2018, 140, 12442-12450). The reaction was refluxed for 6h. After cooling down, the product was precipitated and filtered off. The product was dried in vacuum after washing with water, as a white solid (80%). Heptanoic acid hydrazide: ¹H NMR (500 MHz, DMSO-d₆) δ = 8.88 (s, 1H), 4.03 (s, 1H), 1.96 (t, J=7.4, 2H), 1.43 (p, J= 7.2, 2H), 1.20 (dtd, J=12.6, 8.6, 8.0, 4.6, 6H), 0.82 (t, J=6.9, 3H); ¹³C NMR (126 MHz, DMSO-d₆) δ = 172.20, 33.95, 31.54, 28.86, 25.72, 22.54, 14.46; HR- ESI-MS calculated for C₇H₁₆N₂O [M+H]⁺: 145.21, found 145.18.

References:

WO2021/119606,2021,A1 Location in patent:Paragraph 0175; 0186-0187; 0206; 0209-0210

2528-61-2 Synthesis