Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl synthesis
- Product Name:Hexahydro-oxazolo[3,4-a]pyrazin-3-one HCl
- CAS Number:1020349-31-8
- Molecular formula:C6H11ClN2O2
- Molecular Weight:178.6167
![TERT-BUTYL 3-OXOTETRAHYDRO-1H-OXAZOLO[3,4-A]PYRAZINE-7(3H)-CARBOXYLATE](/CAS2/GIF/935544-47-1.gif)
935544-47-1
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$1103.00/1g
1020349-31-8
48 suppliers
$45.00/50mg
Yield:1020349-31-8 93%
Reaction Conditions:
with hydrogenchloride in dichloromethane;ethyl acetate at 20; for 0.833333 h;Inert atmosphere;
Steps:
125.1 Step 1) : tetrahydro-1H-oxazolo [3, 4-a] pyrazin-3 (5H) -one hydrochloride
To a solution of tert-butyl 3-oxotetrahydro-1H-oxazolo [3, 4-a] pyrazine-7 (3H) -carboxylate (100 mg, 0.41 mmol) in DCM (4 mL) was added a HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 50 min and concentrated to give the title compound as a thick solid (68 mg, 93) .1H NMR (400 MHz, CD3OD) : δ ppm 4.53-4.58 (m, 1H) , 4.20-4.28 (m, 1H) , 4.13-4.16 (m, 1H) , 3.97-4.02 (m, 1H) , 3.53-3.57 (m, 1H) , 3.37-3.45 (m, 2H) , 3.08-3.14 (m, 2H) and MS-ESI: m/z 143.20 [M+H-HCl] +.
References:
WO2016/34134,2016,A1 Location in patent:Paragraph 00688
301673-16-5
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$15.00/250mg
1020349-31-8
48 suppliers
$45.00/50mg
129799-08-2
172 suppliers
$11.00/250mg
1020349-31-8
48 suppliers
$45.00/50mg