(3aR,6aS)-rel-hexahydro-1H-Furo[3,4-c]pyrrole (Relative struc) synthesis

Yield: 91%

Reaction Conditions:

with hydrogen;palladium over charcoal in methanol for 3 h;

Steps:

99.E
Part E: Hexahydro-1H-furo[3,4-c]pyrrole. To a degassed solution of MeOH (5 mL) was added phenylmethyl tetra hydro- 1 H- furo[3,4-c]pyrrole-5(3H)-carboxylate (170 mg, 0.68 mmol) followed by Pd/C (40 mg). Stirring under a hydrogen balloon for 3 hours followed by filtration of the catalyst and evaporation of the solvent yielded hexahydro-1 H-furo[3,4-c]pyrrole (70 mg, 91%). LCMS: (M+H)⁺: Not detected.

References:

SMITHKLINE BEECHAM CORPORATION WO2009/61879, 2009, A1 Location in patent:Page/Page column 137