ChemicalBook CAS DataBase List HYDRIDE-L

HYDRIDE-L synthesis

4synthesis methods

Product Name:HYDRIDE-L
CAS Number:41639-74-1
Molecular formula:C18H22O4
Molecular Weight:302.36

2H-Cyclopenta[b]furan-2-one, 5-(benzoyloxy)hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]-, (3aR,4R,5R,6aS)-

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Yield: 83%

Reaction Conditions:

with potassium carbonate in methanol at 25; for 2 h;

Steps:

1.5 Step 5: Preparation of the compound of formula (IV) (3aR,4R,5R,6aS)-5-hydroxy-4-[(3S)-3-hydroxy-5-phenylpent-1-en-1-yl]-hexahydro-2H-cyclopenta[b]furan-2-one
To a 100 ml 3-neck flask was added the compound of formula III (2 g, 4.92 mmol, 1 eq) prepared in step 4 in 20 ml of MeOH While the dissolution and stirred at 25 K2CO3 (0.9 g, 6.4 mmol, 1.3 eq) was stirred added to the reaction. The reaction was stirred for 2 hours at 25 and complete the reaction. 70 ml of distilled water was added at 25 and stirred for 10 minutes, The pH was adjusted to 2 by the addition of 10% citric acid and extracted three times with 20 ml of ethyl acetate. The organic layer was dried over Na2SO4, Filtered and concentrated under reduced pressure. Crude was subjected to a flash column of ethyl acetate: hexane = 2: 1 to obtain a clear liquid compound (1.25 g, 83%).

References:

MIRAE FINE CHEMICAL CO LTD[KR];Jeong, Jin Hyun;Sim, Yoo Lan;Yang, Woo Lam;Hwang, Sung Kwan;Park, Jang Ha;Choe, Seon Hee KR2017/25682, 2017, A Location in patent:Paragraph 0093; 0120-0122

[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl] -2-oxo-2H-cyclopenta[b]furan-5-yl ester

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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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References

41162-19-0 Synthesis

Dimethyl (2-oxo-4-phenylbutyl)phosphonate

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References

HYDRIDE-L Related Search:

(3aR,4R,5R,6aS)-5-(Benzoyloxy)hexahydro-4-[(1E)-3-oxo-5-phenyl-1-pentenyl]-2H-cyclopenta[b]furan-2-one (-)-Corey Lactone Diol Dimethyl (2-oxo-4-phenylbutyl)phosphonate (5-(ethylamino)-5-oxopentyl)triphenylphosphonium bromide