ChemicalBook CAS DataBase List Imidazo[1,2-a]pyridin-8-ol (9CI)

Imidazo[1,2-a]pyridin-8-ol (9CI) synthesis

3synthesis methods

Product Name:Imidazo[1,2-a]pyridin-8-ol (9CI)
CAS Number:69214-22-8
Molecular formula:C7H6N2O
Molecular Weight:134.14

96428-16-9
41 suppliers
$60.00/100mg

69214-22-8
69 suppliers
$44.00/1g

Yield:69214-22-8 93%

Reaction Conditions:

with palladium on activated charcoal;hydrogen at 25; under 2585.81 Torr;

Steps:

70.2 Step 2: imidazo[l,2-a]pyridin-8-ol

To a solution of 8-benzyloxyimidazo[l,2-a]pyridine (0.9 g, 4.0 mmol) in EtOH (20 mL) was added Pd/C (0.2 g, 10% purity) under N2 atmosphere. The suspension was degassed in vacuum and purged with H2 for 3 times. The mixture was stirred under H2 (50 Psi) at 25 °C for 16 hrs. The reaction mixture was filtered through a pad of celite to remove Pd/C. The filtrate was concentrated in vacuum to afford the title compound (0.5 g, 93% yield) as a white solid, which was used in the next step without purification. LCMS: m/z 135.2 [M+H]⁺.

References:

WO2021/154842,2021,A1 Location in patent:Paragraph 0718; 0723-0725

24016-03-3 Synthesis

24016-03-3
337 suppliers
$5.00/1g

69214-22-8
69 suppliers
$44.00/1g

References

100592-11-8
30 suppliers
$68.00/1g

69214-22-8
69 suppliers
$44.00/1g

References

Imidazo[1,2-a]pyridin-8-ol (9CI) Related Search:

Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI) IMIDAZO[1,2-A]PYRIMIDINE-2-CARBOXYLIC ACID ETHYL ESTER 2-Methylimidazo[1,2-a]pyridin-8-ol 8-BENZYLOXY-2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 8-BENZYLOXY-3-IODO-IMIDAZO[1,2-A]PYRIDINE 8-BENZYLOXY-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER