Imidazole synthesis
- Product Name:Imidazole
- CAS Number:36364-49-5
- Molecular formula:C10H10N2O3
- Molecular Weight:0
Yield:36364-49-5 95.3%
Reaction Conditions:
in ethanol at 60;Molecular sieve;Solvent;
Steps:
1 Example 1
138 g of medicinal grade salicylic acid and 68 g of pharmaceutical grade imidazole after pretreatment after passing through a 200 mesh sieve were placed in the ball mill respectively.Grinding starts at 120 r/min at full speed and is wetted with 5 ml of medicinal ethanol and then added to the material every 20 minutes.5 ml of medicinal ethanol until the end of the reaction. Grinding process control reaction temperature below 60 °C, reaction time 2.5 ~ 3h, to the correctThe reaction reaches the end point. The product was taken out and dried at 70° C. to obtain 205.8 g of white crystalline powdered salicylic acid imidazole. The yield was95.3%.
References:
CN107382868,2017,A Location in patent:Paragraph 0006; 0014-0017
