Indole-3-carbinol synthesis
- Product Name:Indole-3-carbinol
- CAS Number:700-06-1
- Molecular formula:C9H9NO
- Molecular Weight:147.17
487-89-8
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$6.00/10g
700-06-1
621 suppliers
$10.00/1g
Yield:700-06-1 95.2%
Reaction Conditions:
with sodium tetrahydridoborate in ethanol at 20 - 45; for 2 h;Green chemistry;Temperature;
Steps:
1.S2-1.S3; 8-10 S2, preparation of crude indole-3-methanol
Take 100 g of indole-3-carboxaldehyde in a 1000 mL three-necked flask, add 200 g of ethanol, stir, disperse and dissolve at room temperature, then add 45 g of sodium borohydride, slowly heat up to 45 ° C, react for 2 hours, HPLC traces and detects no raw material indole-3 -formaldehyde, then filtered, the filter cake was sodium metaborate, sodium metaborate was collected, and the filtrate was concentrated to obtain crude indole-3-methanol.S3. PurificationThe crude indole-3-methanol obtained in S2 was recrystallized from ethanol to obtain purified indole-3-methanol with a yield of 95.2% and a purity of more than 99.0%. The purity analysis results are shown in Figure 2.
References:
CN113845463,2021,A Location in patent:Paragraph 0030-0031; 0035-0038; 0051-0058; 0063-0066
942-24-5
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700-06-1
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$10.00/1g
487-89-8
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124-40-3
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700-06-1
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87-52-5
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$16.00/5g
487-89-8
594 suppliers
$6.00/10g
700-06-1
621 suppliers
$10.00/1g
22259-53-6
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$74.00/1g
93742-14-4
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