ChemicalBook CAS DataBase List Ioversol

Ioversol synthesis

8synthesis methods

Product Name:Ioversol
CAS Number:87771-40-2
Molecular formula:C18H24I3N3O9
Molecular Weight:807.11

77868-40-7 Synthesis

77868-40-7
83 suppliers
$250.00/1mg

107-07-3
3 suppliers
$18.30/50ml

87771-40-2
174 suppliers
$32.00/5mg

Yield:87771-40-2 98%

Reaction Conditions:

with dipotassium hydrogenphosphate in water; pH=12 - 13 at 25; for 36 h;Reagent/catalyst;Solvent;Temperature;

Steps:

1-10 Example 3: Preparation of Ioversol
In a 1000 mL reactor,Add 200mL of water,Dipotassium hydrogen phosphate 11.8 g (0.068 mol),Compound I 76.3 g (0.1 mol),Turn on the agitation,Warming up to 25 ° C,After stirring evenly,Start slowly adding an aqueous solution of Chloroethanol (9.66 g (0.12 mol) and 100 ml of water).At the same time, 34.2 g (0.059 mol) of 30 wt% dipotassium hydrogen phosphate solution was added dropwise.Control the pH of the reaction system at 12-13,The addition of 6h is completed.The reaction was kept for 30 hours. After cooling to room temperature, it was neutralized with dilute hydrochloric acid, filtered, and the filtrate was desalted by anionic cation exchange resin (same as in Example 1). The filtrate was concentrated and recrystallized three times with water to obtain 79 g of Ioversol, HPLC ≥ 99.5%, yield 98%. .

References:

Zhejiang Haizhou Pharmaceutical Co., Ltd.;Wang Junhua;Huai Zheming;Yuan Jilei;She Ying;Liu Yiping;Jiang Donghua;Ran Bo CN110156623, 2019, A Location in patent:Paragraph 0028-0048

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