![](/CAS/GIF/92339-11-2.gif)
Iodixanol synthesis
- Product Name:Iodixanol
- CAS Number:92339-11-2
- Molecular formula:C35H44I6N6O15
- Molecular Weight:1550.18
Iodixanol, developed by Nycomed in Norway, is a new type of non-ionic X-ray contrast agent, the only one that is isotonic with plasma when applied intravascularly. Iodixanol can be synthesized by three-step reaction using N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide as raw material.
![5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide](/CAS/GIF/31127-80-7.gif)
31127-80-7
222 suppliers
$24.00/5g
![Epichlorohydrin](/CAS/GIF/106-89-8.gif)
106-89-8
733 suppliers
$9.00/10g
![Iohexol](/CAS/GIF/66108-95-0.gif)
66108-95-0
387 suppliers
$28.00/1g
![Iodixanol](/CAS/GIF/92339-11-2.gif)
92339-11-2
233 suppliers
$201.00/500MG
Yield:92339-11-2 86.3% ,66108-95-0 7.5%
Reaction Conditions:
with hydrogenchloride;boric acid;potassium hydroxide in water; pH=10 - 11;Product distribution / selectivity;Industry scale;
Steps:
1
Compound A (1120.5 kg, 1.50 kmol) was dissolved in a solution of KOH (140.0 kg, 2.25 kmol) in water (1232.6 kg), the temperature was controlled to below 20°C, boric acid (64.9 kg, 1.05 kmol) was equally added in a batch manner, and hydrochloric acid (30.4 kg, 0.30 kmol) was added dropwise, followed by epichlorohydrin (83.3 kg, 0.90 kmol), which was added dropwise. The pH during the reaction is 10-11. The reaction was monitored and a sample was analyzed by HPLC. The reaction was quenched by adding water (1232.6 kg) and adjusting the pH to within the range 5-6 with 18% of hydrochloric acid when the content of Compound A was below 5%.The reaction mixture was then decolorized with active charcoal and filtered. The filtrate contained 86.3% of iodixanol, 7.5% of iohexol, 2.9% of compound A and 2.7% of O-alkylated by-products and other impurities by HPLC analysis.
References:
WO2011/63551,2011,A1 Location in patent:Page/Page column 15-16
![2-(1,3-dichloropropan-2-yloxy)oxane](/CAS/20210111/GIF/28659-12-3.gif)
28659-12-3
1 suppliers
inquiry
![5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide](/CAS/GIF/31127-80-7.gif)
31127-80-7
222 suppliers
$24.00/5g
![Iodixanol](/CAS/GIF/92339-11-2.gif)
92339-11-2
233 suppliers
$201.00/500MG
![5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide](/CAS/GIF/31127-80-7.gif)
31127-80-7
222 suppliers
$24.00/5g
![Epichlorohydrin](/CAS/GIF/106-89-8.gif)
106-89-8
733 suppliers
$9.00/10g
![Iodixanol](/CAS/GIF/92339-11-2.gif)
92339-11-2
233 suppliers
$201.00/500MG
![1,3-Dichloro-2-propanol](/CAS/GIF/96-23-1.gif)
96-23-1
281 suppliers
$10.00/1g
![5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide](/CAS/GIF/31127-80-7.gif)
31127-80-7
222 suppliers
$24.00/5g
![Iodixanol](/CAS/GIF/92339-11-2.gif)
92339-11-2
233 suppliers
$201.00/500MG
![5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide](/CAS/GIF/31127-80-7.gif)
31127-80-7
222 suppliers
$24.00/5g
![Iohexol](/CAS/GIF/66108-95-0.gif)
66108-95-0
387 suppliers
$28.00/1g
![Iodixanol](/CAS/GIF/92339-11-2.gif)
92339-11-2
233 suppliers
$201.00/500MG